Powering Next-Generation Genomic Sequencing with Advantech’s Edge Server

As precision medicine and genetic research accelerate, there is a growing demand for sequencing technologies that combine accuracy, speed, and scalability. A global genomics technology company sought to transform high-fidelity (HiFi) sequencing by introducing a compact sequencing platform that delivers exceptional read accuracy and high throughput. To support this innovation, they required a robust computing backbone system that could handle intensive data processing, real-time analytics, and modular scalability while maintaining a compact physical footprint.

To power this new-generation sequencing platform the system needed to fulfill the following critical requirements: 

• High-performance computing capabilities to process and analyze vast volumes of genomic data in real time
• Compact form factor suitable for integration into the instrument
• High-speed data transfer interfaces to ensure seamless data flow from sequencing modules to the computing unit
• Industrial-grade reliability to support 24/7 operations in laboratory environments
• Scalability and customization for future algorithm enhancements and performance upgrades
• High Data Storage Capacity
  

The sequencing platform integrated Advantech’s SKY-820V3, a 2U dual-socket edge server optimized for high-density AI and HPC workloads at the edge and in data-rich environments.

Key system features include:

• Dual 5th/4th Gen Intel® Xeon® Scalable Processors, ensuring ultra-fast genomic computations
• 450mm short-depth server
• 16 DDR5 ECC-REG RDIMM/LRDIMM—ideal for memory-intensive bioinformatics workflows
• Configurable PCIe 5.0 options: 4 x PCIe x16 (FHFL, 10.5") or 2 x PCIe x16 (FHFL, 10.5"), 2 x PCIe x8 (FHFL, 10.5"), and 2 x PCIe x8 (FHHL) expansion slots for GPU acceleration, FPGA, or high-speed network interface cards—empowering real-time data processing.

Advantech also provided BIOS customization, long-life-cycle product support, and integration consulting, enabling smooth deployment into the final sequencing system. 

Learn More:  SKY-820V3 Video

• Exceptional Performance: SKY-820V3's dual 5th/4th Gen Intel® Xeon® processors architecture and Gen5 PCIe expansion enable rapid parallel processing of large genomic datasets
• Large Memory Bandwidth: 2 TB of DDR5 memory ensures low-latency access to vast bioinformatics workloads
• Edge-Ready Design: Its 2U form factor, front-access maintenance, and ruggedized design support seamless integration into the instruments
• GPU-Ready Architecture: Supports multiple GPU cards for accelerating AI inference and machine learning applications in genomics
• High Reliability: Designed for 24/7 operation with redundant PSU and remote management, minimizing downtime and service complexity
• Future-Proof Scalability: PCIe Gen5 and modular expandability provide the foundation for future algorithm updates and performance growth
  

By integrating Advantech’s SKY-820V3 server into the sequencing platform, the client successfully delivered a next-generation DNA sequencing solution that meets the demands of modern research and clinical diagnostics. This case exemplifies how Advantech’s high-performance edge servers are enabling precision medicine and unlocking new possibilities in genomic science through compact, scalable, and future-ready computing infrastructure.